This is another remedy that has been neglected by the vast majority of practicing physicians. It is made from the inner bark and root of the East Indian mango tree. My attention was accidentally called to it by a brief description of the drug and its action in an edition of king’s Dispensary some twenty years ago. This led to my using it first in some chronic diarrhoeas which had heretofore baffled all kinds of treatment. My own pleasure at its action was only excelled by that of those who were treated. Since that time Mangifera Indica has been one of my constant remedial agents, for, in these times, when so many of our patients present themselves with the atonic condition so prominent, there are many places where this drug fits in admirably. Atony and sluggishness of the circulation seems to be the keynote for its use. Even the acute diarrhoeas with these two symptoms will be frequently benefited by its use. It will arrest the fluxes of the various mucous membranes wherever situated if they are associated with atony. In several cases where pregnancy has been complicated by varicose veins, the use of this drug has enabled the women to go to full term without much discomfort. These were cases where in previous pregnancies resort to elastic stockings had been necessary. My dosage has been from the fraction of a drop to two drops at a dose. The more chronic the case the smaller the dose, and the longer it must be continued. Usually I add 3i of Mangifera to 3iv of aqua and direct the patient to take 3i every one, two, or three hours. This remedy has also proved of much value in cases of epistaxis where the state of atony is a prominent feature. Where the haemorrhage has been very profuse I have increased the dose to three and occasionally five drops to the dose. My experience has taught me that the larger doses should be used with caution Give the least possible amount of medicine that will relieve the patient is a good and safe rule to follow, not only with Mangifera Indica, but with any form of drug medication. We should never forget that the physician’s province in the “practice of medicine” is simply to assist “nature.” He who attempts more makes a mistake.